Recursion's First Clinical Validation of AI-Enabled Platform with Rare Disease Drug REC-4881

Recursion
715,499 views December 17, 2025

AI drug discovery, validated. Recursion recently announced the first clinical validation of its AI-enabled drug discovery platform – positive Phase 1b/2 data for the ongoing TUPELO study evaluating its AI-identified drug, REC-4881, in Familial Adenomatous Polyposis (FAP). This progressive rare disease affects more than 50,000 people in the U.S. and EU and has no FDA-approved treatments. It results in hundreds to thousands of polyps developing in the colon, and requires a lifetime of invasive surveillance and surgery. Recursion used AI not only to deliver the first potential treatment for this disease but also to quantify – for the first time at scale – the true natural progression of polyp burden in the trial-relevant population. It demonstrates the incredible breakthroughs that can come from merging proprietary data and AI – and the tangible impact on patient lives. 👉 See the full study results here: https://ir.recursion.com/news-releases/news-release-details/positive-phase-1b2-results-ongoing-rec-4881-tupelo-trial-0 #raredisease #fap #clinicaltrial #AI #drugdiscovery

Keyboard shortcuts

On. Switch them off if they collide with your assistive tools; ? still opens this sheet.

Go to

Press g then the letter.

  • gh Latest
  • gs Sources
  • gm Media
  • gv Videos
  • gp Podcasts
  • gc Calendar
  • gd Decoder
  • gz Dataviz
  • ga Datasets
  • gb Blog
  • gk Markets
  • gj Careers
  • gn Prompt Notebook

On this page

  • / Focus search, where there is one
  • t Back to top
  • ? This list
  • Esc Close