The Playbook To Building AI-Driven Innovation at Scale with Karen Pfeifer of Pythian

Informatica
48 views August 6, 2026

AI this, AI that - but how many of us are actually extracting its complete value and making it work for us? In this episode of Bringing Data and AI to Life, host and GVP Solutions Sales and Business Development at Informatica, Amy Horowitz sits down with Karen Pfeifer, Chief AI Officer at Pythian, to unravel the complexities of enterprise data and AI transformation. What You’ll Learn How to transform raw data assets into strategic business drivers through a data-first, AI-centric approach The framework for measuring data success through concrete business metrics like cost reduction, customer retention, and revenue growth Why organizational culture and change management are crucial for successful AI implementation How to develop cross-functional data strategies that align with specific business outcomes The critical importance of building trusted data foundations before scaling AI initiatives How to navigate the balance between innovation and responsible AI usage in enterprise environments If you enjoyed this episode, make sure to subscribe, rate, and review it on Apple Podcasts and Spotify. Instructions on how to do this are here. This podcast is brought to you by Informatica, the leader in enterprise cloud data management. Links: Karen Pfeifer on LinkedIn: https://www.linkedin.com/in/karen-pfeifer-data-strategy/ Pythian Website: https://www.pythian.com/ Amy Horowitz LinkedIn: https://www.linkedin.com/in/amyhorowitz Informatica Website: https://www.informatica.com/ Data & AI Architecture Summit: https://now.informatica.com/ai-architecture-summit2025.html?Source=INFAPodcast Episode Highlights: 00:00 Welcome to Bringing Data and AI to Life 01:09 Meet Karen Pfeiffer: From Disney to Chief AI Officer 03:23 The Evolution of Data-First AI Strategy 05:09 Measuring Success: Beyond Technical Metrics 07:48 Overcoming Cultural Resistance in AI Adoption 09:23 AI Governance and Responsible Implementation 11:35 Innovation in Data Products: Emmy-Winning Solutions 14:10 Future Trends: Agentic AI and Data Readiness 16:28 Leadership Advice for Emerging Data Leaders 17:47 Closing Thoughts and Informatica's Mission

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